Heart Rate Reduction by Ivabradine Reduces Diastolic Dysfunction and Cardiac Fibrosis
نویسندگان
چکیده
منابع مشابه
Heart rate reduction by ivabradine reduces oxidative stress, improves endothelial function, and prevents atherosclerosis in apolipoprotein E-deficient mice.
BACKGROUND Elevated heart rate is associated with increased cardiovascular morbidity. We hypothesized that selective heart rate reduction may influence endothelial function and atherogenesis and tested the effects of the I(f) current inhibitor ivabradine in apolipoprotein E-deficient mice. METHODS AND RESULTS Male apolipoprotein E-deficient mice fed a high-cholesterol diet were treated with i...
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ژورنال
عنوان ژورنال: Cardiology
سال: 2010
ISSN: 1421-9751,0008-6312
DOI: 10.1159/000322905